The new form of the Hunters. Much like the 121 Alpha Hunters in Resident Evil 1 their attacks have to do with running and jumping around a lot, and using their claws to cause damage. Killing them this time is a little easier than with the Alphas.
Unless your really low on health, or surrounded by a few of them attacking at various times (a real pain to get out of), you probably wont find them to be much of a challenge. Still perhaps you shouldn't get too relaxed about facing them.
When taking them on your weapons of choice for an easy kill would be the Magnum or Assault Rifle. Shotguns work nicely and if you have the distance between yourself and a single one, the Handgun can be used too if your low on good ammo (though you should never be like that).